Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species

Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration. As AAV vectors become an increasingly common platf...

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Detalles Bibliográficos
Autores principales: Fader, Kelly A., Pardo, Ingrid D., Kovi, Ramesh C., Somps, Christopher J., Wang, Helen Hong, Vaidya, Vishal S., Ramaiah, Shashi K., Sirivelu, Madhu P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024379/
https://www.ncbi.nlm.nih.gov/pubmed/35505662
http://dx.doi.org/10.1016/j.omtm.2022.03.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024379/
https://www.ncbi.nlm.nih.gov/pubmed/35505662
http://dx.doi.org/10.1016/j.omtm.2022.03.017

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