Cargando…

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

Airway remodeling is a pathological process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway niche, actively participate in the remodeling proce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wójcik-Pszczoła, Katarzyna, Chłoń-Rzepa, Grażyna, Jankowska, Agnieszka, Ferreira, Bruno, Koczurkiewicz-Adamczyk, Paulina, Pękala, Elżbieta, Wyska, Elżbieta, Pociecha, Krzysztof, Gosens, Reinoud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024446/ https://www.ncbi.nlm.nih.gov/pubmed/35455420 http://dx.doi.org/10.3390/ph15040423

Ejemplares similares

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
por: Wójcik-Pszczoła, Katarzyna, et al.
Publicado: (2020)

Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases
por: Świerczek, Artur, et al.
Publicado: (2022)

Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents
por: Piska, Kamil, et al.
Publicado: (2017)

PK/PD Modeling of the PDE7 Inhibitor—GRMS-55 in a Mouse Model of Autoimmune Hepatitis
por: Świerczek, Artur, et al.
Publicado: (2021)

Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach
por: Świerczek, Artur, et al.
Publicado: (2020)

Fibroblast-to-myofibroblast transition in bronchial asthma
por: Michalik, Marta, et al.
Publicado: (2018)

Similar Safety Profile of the Enantiomeric N-Aminoalkyl Derivatives of Trans-2-Aminocyclohexan-1-ol Demonstrating Anticonvulsant Activity
por: Słoczyńska, Karolina, et al.
Publicado: (2019)

Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity
por: Zygmunt, Małgorzata, et al.
Publicado: (2022)

Saponin Fraction CIL1 from Lysimachia ciliata L. Enhances the Effect of a Targeted Toxin on Cancer Cells
por: Koczurkiewicz-Adamczyk, Paulina, et al.
Publicado: (2023)

In Vitro Biotransformation, Safety, and Chemopreventive Action of Novel 8-Methoxy-Purine-2,6-Dione Derivatives
por: Marć, Małgorzata Anna, et al.
Publicado: (2017)

The Involvement of Xanthone and (E)-Cinnamoyl Chromophores for the Design and Synthesis of Novel Sunscreening Agents
por: Popiół, Justyna, et al.
Publicado: (2020)

Cinnamic Acid Derivatives as Cardioprotective Agents against Oxidative and Structural Damage Induced by Doxorubicin
por: Koczurkiewicz-Adamczyk, Paulina, et al.
Publicado: (2021)

Autophagy modulating agents as chemosensitizers for cisplatin therapy in cancer
por: Gąsiorkiewicz, Bartosz Mateusz, et al.
Publicado: (2020)

Evaluation of Two Novel Hydantoin Derivatives Using Reconstructed Human Skin Model Episkin(TM): Perspectives for Application as Potential Sunscreen Agents
por: Słoczyńska, Karolina, et al.
Publicado: (2022)

KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain
por: Waszkielewicz, Anna, et al.
Publicado: (2022)

In Silico and In Vitro Assessment of Carbonyl Reductase 1 Inhibition Using ASP9521—A Potent Aldo-Keto Reductase 1C3 Inhibitor with the Potential to Support Anticancer Therapy Using Anthracycline Antibiotics
por: Jamrozik, Marek, et al.
Publicado: (2023)

Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group
por: Popiół, Justyna, et al.
Publicado: (2019)

Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy
por: Rapacz, Anna, et al.
Publicado: (2017)

Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice
por: Wyska, Elżbieta, et al.
Publicado: (2015)

Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives
por: Czopek, Anna, et al.
Publicado: (2020)

Synthesis, Anticonvulsant, and Antinociceptive Activity of New 3-(2-Chlorophenyl)- and 3-(3-Chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides
por: Góra, Małgorzata, et al.
Publicado: (2021)

Novel Antibacterial, Cytotoxic and Catalytic Activities of Silver Nanoparticles Synthesized from Acidophilic Actinobacterial SL19 with Evidence for Protein as Coating Biomolecule
por: Wypij, Magdalena, et al.
Publicado: (2022)

Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice
por: Socała, Katarzyna, et al.
Publicado: (2012)

A Comparative Survey of Anti-Melanoma and Anti-Inflammatory Potential of Usnic Acid Enantiomers—A Comprehensive In Vitro Approach
por: Galanty, Agnieszka, et al.
Publicado: (2021)

S(+)-(2E)-N-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy
por: Gunia-Krzyżak, Agnieszka, et al.
Publicado: (2020)

Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method
por: Szafarz, Małgorzata, et al.
Publicado: (2017)

Antiplatelet Effects of Selected Xanthine-Based Adenosine A(2A) and A(2B) Receptor Antagonists Determined in Rat Blood
por: Kubacka, Monika, et al.
Publicado: (2023)

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT(6)R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity
por: Canale, Vittorio, et al.
Publicado: (2022)

Cunninghamella as a Microbiological Model for Metabolism of Histamine H(3) Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine
por: Pękala, Elżbieta, et al.
Publicado: (2012)

Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α(1A)/α(1D)-Adrenergic Receptor Antagonist with Potential Uroselective Profile
por: Canale, Vittorio, et al.
Publicado: (2018)

Interleukin-11 disrupts alveolar epithelial progenitor function
por: Kortekaas, Rosa K., et al.
Publicado: (2023)

Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids
por: Ptasinski, Victoria, et al.
Publicado: (2023)

Effects of Phosphodiesterase 4 Inhibition on Alveolarization and Hyperoxia Toxicity in Newborn Rats
por: Méhats, Céline, et al.
Publicado: (2008)

Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust
por: Hou, Xiaomin, et al.
Publicado: (2019)

Cholinergic Regulation of Airway Inflammation and Remodelling
por: Kolahian, Saeed, et al.
Publicado: (2012)

WNT-5A: signaling and functions in health and disease
por: Kumawat, Kuldeep, et al.
Publicado: (2015)

The mode of action of anticholinergics in asthma
por: Gosens, Reinoud, et al.
Publicado: (2018)

Effect of sildenafil on the activity of some antidepressant drugs and electroconvulsive shock treatment in the forced swim test in mice
por: Socała, Katarzyna, et al.
Publicado: (2016)

Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors
por: Wu, Xinhui, et al.
Publicado: (2019)

Endothelial follistatin-like-1 regulates the postnatal development of the pulmonary vasculature by modulating BMP/Smad signaling
por: Tania, Navessa P., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qaetelgh4c6njt7qaush9b98k4