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Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity
In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of mutagens, driving viral populations to extinction. Extinction catastrophe can be experimentally induced by promutagenic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024455/ https://www.ncbi.nlm.nih.gov/pubmed/35458571 http://dx.doi.org/10.3390/v14040841 |