The Biological Fate of a Novel Anticancer Drug Candidate TNBG-5602: Metabolic Profile, Interaction with CYP450, and Pharmacokinetics in Rats

TNBG-5602, a novel anticancer drug candidate, may induce the expression of PPARγ, causing targeted lipotoxicity in cancer tissues. In this study, the in vivo metabolism in rats, in vitro metabolism in recombinant cytochromes, molecular docking for the CYP binding site, and pharmacokinetics in rats w...

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Detalles Bibliográficos
Autores principales: Li, Rui, Zhou, Sha, Gan, Zongjie, Wang, Lijuan, Yu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024597/
https://www.ncbi.nlm.nih.gov/pubmed/35458793
http://dx.doi.org/10.3390/molecules27082594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024597/
https://www.ncbi.nlm.nih.gov/pubmed/35458793
http://dx.doi.org/10.3390/molecules27082594

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