Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy

Nuclear export protein 1 (XPO1), a member of the nuclear export protein-p (Karyopherin-P) superfamily, regulates the transport of “cargo” proteins. To facilitate this important process, which is essential for cellular homeostasis, XPO1 must first recognize and bind the cargo proteins. To inhibit thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Zheyuan, Zhuang, Weihao, Li, Kang, Guo, Yu, Qu, Bingxue, Chen, Sikang, Gao, Jian, Liu, Jing, Xu, Lei, Dong, Xiaowu, Che, Jinxin, Li, Qimeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024667/
https://www.ncbi.nlm.nih.gov/pubmed/35458742
http://dx.doi.org/10.3390/molecules27082543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024667/
https://www.ncbi.nlm.nih.gov/pubmed/35458742
http://dx.doi.org/10.3390/molecules27082543

Ejemplares similares