Functional Characterization of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G)

Human wild type (wt) cardiac α-actin and its mutants p.A295S or p.R312H and p.E361G correlated with hypertrophic or dilated cardiomyopathy, respectively, were expressed by using the baculovirus/Sf21 insect cell system. The c-actin variants inhibited DNase I, indicating maintenance of their native st...

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Detalles Bibliográficos
Autores principales: Hassoun, Roua, Erdmann, Constanze, Schmitt, Sebastian, Fujita-Becker, Setsuko, Mügge, Andreas, Schröder, Rasmus R., Geyer, Matthias, Borbor, Mina, Jaquet, Kornelia, Hamdani, Nazha, Mannherz, Hans Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024677/
https://www.ncbi.nlm.nih.gov/pubmed/35457283
http://dx.doi.org/10.3390/ijms23084465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024677/
https://www.ncbi.nlm.nih.gov/pubmed/35457283
http://dx.doi.org/10.3390/ijms23084465

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