In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions

Inhibition of human DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) by different chiral lipophilic nucleoside derivatives was studied. New Tdp1 inhibitors were found in the series of the studied compounds with IC(50) = 2.7–6.7 μM. It was shown that D-lipophilic nucleoside derivatives manife...

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Detalles Bibliográficos
Autores principales: Dyrkheeva, Nadezhda S., Chernyshova, Irina A., Ivanov, Georgy A., Porozov, Yuri B., Zenchenko, Anastasia A., Oslovsky, Vladimir E., Zakharenko, Alexandra L., Nasyrova, Darina I., Likhatskaya, Galina N., Mikhailov, Sergey N., Lavrik, Olga I., Drenichev, Mikhail S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024977/
https://www.ncbi.nlm.nih.gov/pubmed/35458631
http://dx.doi.org/10.3390/molecules27082433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024977/
https://www.ncbi.nlm.nih.gov/pubmed/35458631
http://dx.doi.org/10.3390/molecules27082433

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