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Cerebroventricular Injection of Pgk1 Attenuates MPTP-Induced Neuronal Toxicity in Dopaminergic Cells in Zebrafish Brain in a Glycolysis-Independent Manner

Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons. While extracellular Pgk1 (ePgk1) is reported to promote neurite outgrowth, it remains unclear if it can affect the survival of dopaminergic cells. To address this, we employed cerebroventricular microinjection (CV...

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Detalles Bibliográficos
Autores principales: Lin, Cheng-Yung, Tseng, Hsiang-Chien, Chu, Yu-Rong, Wu, Chia-Lun, Zhang, Po-Hsiang, Tsai, Huai-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025024/
https://www.ncbi.nlm.nih.gov/pubmed/35456967
http://dx.doi.org/10.3390/ijms23084150