The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced Drosophila Model of Peripheral Neuropathy

Paclitaxel is a widely used anticancer drug that induces dose-limiting peripheral neuropathy. Mitochondrial dysfunction has been implicated in paclitaxel-induced neuronal damage and in the onset of peripheral neuropathy. We have previously shown that the expression of PINK1, a key mediator of mitoch...

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Detalles Bibliográficos
Autores principales: Jang, Hye-Ji, Kim, Young-Yeon, Lee, Kang-Min, Shin, Jung-Eun, Yun, Jeanho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025238/
https://www.ncbi.nlm.nih.gov/pubmed/35453613
http://dx.doi.org/10.3390/biomedicines10040863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025238/
https://www.ncbi.nlm.nih.gov/pubmed/35453613
http://dx.doi.org/10.3390/biomedicines10040863

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