Elevating SOX2 Downregulates MYC through a SOX2:MYC Signaling Axis and Induces a Slowly Cycling Proliferative State in Human Tumor Cells

SIMPLE SUMMARY: The ability of slowly cycling/infrequently proliferating tumor cells to evade treatment with therapies that target actively proliferating tumor cells represents a major clinical challenge. Previous studies established that high levels of SOX2 in both fetal and tumor cells restrict ce...

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Detalles Bibliográficos
Autores principales: Metz, Ethan P., Wilder, Phillip J., Popay, Tessa M., Wang, Jing, Liu, Qi, Kalluchi, Achyuth, Rowley, M. Jordan, Tansey, William P., Rizzino, Angie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025961/
https://www.ncbi.nlm.nih.gov/pubmed/35454854
http://dx.doi.org/10.3390/cancers14081946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025961/
https://www.ncbi.nlm.nih.gov/pubmed/35454854
http://dx.doi.org/10.3390/cancers14081946

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