Cargando…

Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes

Dimethyl fumarate (DMF) has emerged as a first-line therapy for relapsing-remitting multiple sclerosis (RRMS). This treatment, however, has been limited by adverse effects, which has prompted development of novel derivatives with improved tolerability. We compared the effects of fumarates on gene ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Swindell, William R., Bojanowski, Krzysztof, Chaudhuri, Ratan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026097/
https://www.ncbi.nlm.nih.gov/pubmed/35455458
http://dx.doi.org/10.3390/ph15040461