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A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes
Globally, autosomal recessive IFNAR1 deficiency is a rare inborn error of immunity underlying susceptibility to live attenuated vaccine and wild-type viruses. We report seven children from five unrelated kindreds of western Polynesian ancestry who suffered from severe viral diseases. All the patient...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026234/ https://www.ncbi.nlm.nih.gov/pubmed/35442418 http://dx.doi.org/10.1084/jem.20220028 |