Apoptotic and DNA Damage Effect of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose in Cisplatin-Resistant Non-Small Lung Cancer Cells via Phosphorylation of H(2)AX, CHK2 and p53

Herein, the apoptotic mechanism of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) was examined in cisplatin-resistant lung cancer cells. PGG significantly reduced viability; increased sub-G1 accumulation and the number of terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL)-...

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Detalles Bibliográficos
Autores principales: Kim, Ji-Hyun, Im, Eunji, Lee, Jihyun, Lee, Hyo-Jung, Sim, Deok Yong, Park, Ji Eon, Ahn, Chi-Hoon, Kwon, Hyeon Hee, Shim, Bum Sang, Kim, Bonglee, Kim, Sung-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026497/
https://www.ncbi.nlm.nih.gov/pubmed/35456022
http://dx.doi.org/10.3390/cells11081343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026497/
https://www.ncbi.nlm.nih.gov/pubmed/35456022
http://dx.doi.org/10.3390/cells11081343

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