Charged Residue Implantation Improves the Affinity of a Cross-Reactive Dengue Virus Antibody

Dengue virus (DENV) has four serotypes that complicate vaccine development. Envelope protein domain III (EDIII) of DENV is a promising target for therapeutic antibody development. One EDIII-specific antibody, dubbed 1A1D-2, cross-reacts with DENV 1, 2, and 3 but not 4. To improve the affinity of 1A1...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Huiling, Tan, Jie, Zhou, Bingjie, Guan, Xiaotong, Zhong, Qiaoxian, Wang, Jiaqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027083/
https://www.ncbi.nlm.nih.gov/pubmed/35457015
http://dx.doi.org/10.3390/ijms23084197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027083/
https://www.ncbi.nlm.nih.gov/pubmed/35457015
http://dx.doi.org/10.3390/ijms23084197

Ejemplares similares