Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity

Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against β-ketoacyl-[acyl carrier protein] synthase II (FabF) and β-ketoacyl-[acyl carrier protein] synthase I (FabB), while the poor pharmacokinetics has prevented its...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Youchao, Li, Yuling, Wen, Zhongqing, Ruiz, Claudia H., Weng, Xiang, Cameron, Michael D., Duan, Yanwen, Huang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027111/
https://www.ncbi.nlm.nih.gov/pubmed/35453177
http://dx.doi.org/10.3390/antibiotics11040425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027111/
https://www.ncbi.nlm.nih.gov/pubmed/35453177
http://dx.doi.org/10.3390/antibiotics11040425

Ejemplares similares