Cargando…

First-in-Human Study of [(68)Ga]Ga-NODAGA-E[c(RGDyK)](2) PET for Integrin α(v)β(3) Imaging in Patients with Breast Cancer and Neuroendocrine Neoplasms: Safety, Dosimetry and Tumor Imaging Ability

Arginine-Glycine-Aspartate (RGD)-recognizing cell surface integrins are involved in tumor growth, invasiveness/metastases, and angiogenesis, and are therefore an attractive treatment target in cancers. The subtype integrin α(v)β(3) is upregulated on endothelial cells during angiogenesis and on tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clausen, Malene Martini, Carlsen, Esben Andreas, Christensen, Camilla, Madsen, Jacob, Brandt-Larsen, Malene, Klausen, Thomas Levin, Holm, Søren, Loft, Annika, Berthelsen, Anne Kiil, Kroman, Niels, Knigge, Ulrich, Kjaer, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027224/ https://www.ncbi.nlm.nih.gov/pubmed/35453899 http://dx.doi.org/10.3390/diagnostics12040851

Ejemplares similares

First in-human radiation dosimetry of (68)Ga-NODAGA-RGDyK
por: Gnesin, Silvano, et al.
Publicado: (2017)

[(68)Ga]Ga-DFO-c(RGDyK): Synthesis and Evaluation of Its Potential for Tumor Imaging in Mice
por: Krajcovicova, Sona, et al.
Publicado: (2021)

Association between [(68)Ga]NODAGA-RGDyK uptake and dynamics of angiogenesis in a human cell-based 3D model
por: Grönman, Maria, et al.
Publicado: (2021)

Angiogenesis PET Tracer Uptake ((68)Ga-NODAGA-E[(cRGDyK)](2)) in Induced Myocardial Infarction in Minipigs
por: Rasmussen, Thomas, et al.
Publicado: (2016)

[(68)Ga]Ga-NODAGA-E[(cRGDyK)](2) Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction
por: Bentsen, Simon, et al.
Publicado: (2021)

Angiogenesis PET Tracer Uptake ((68)Ga-NODAGA-E[(cRGDyK)](2)) in Induced Myocardial Infarction and Stromal Cell Treatment in Minipigs
por: Rasmussen, Thomas, et al.
Publicado: (2018)

[(68)Ga]Ga-NODAGA-E[(cRGDyK)](2) and [(64)Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy
por: Follin, Bjarke, et al.
Publicado: (2023)

[(68)Ga]Ga-NODAGA-E[(cRGDyK)](2) angiogenesis PET following myocardial infarction in an experimental rat model predicts cardiac functional parameters and development of heart failure
por: Bentsen, Simon, et al.
Publicado: (2023)

[(68)Ga]Ga-NODAGA-E[(cRGDyK)](2) PET and hyperpolarized [1-(13)C] pyruvate MRSI (hyperPET) in canine cancer patients: simultaneous imaging of angiogenesis and the Warburg effect
por: Clemmensen, Andreas, et al.
Publicado: (2020)

Evaluation of [(68)Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis
por: Jahandideh, Arghavan, et al.
Publicado: (2021)

PET-Based Human Dosimetry of (68)Ga-NODAGA-Exendin-4, a Tracer for β-Cell Imaging
por: Boss, Marti, et al.
Publicado: (2020)

(64)Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and Integrin α (V) β (3) Expression in Human Neuroendocrine Tumor Xenografts
por: Oxboel, Jytte, et al.
Publicado: (2012)

PET Probes for Preclinical Imaging of GRPR-Positive Prostate Cancer: Comparative Preclinical Study of [(68)Ga]Ga-NODAGA-AMBA and [(44)Sc]Sc-NODAGA-AMBA
por: Kálmán-Szabó, Ibolya, et al.
Publicado: (2022)

Preparation, Characterization, and Radiolabeling of [(68)Ga]Ga-NODAGA-Pamidronic Acid: A Potential PET Bone Imaging Agent
por: Ashhar, Zarif, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of a c(RGDyK) Peptide Conjugate of SRPIN803
por: Leonidis, George, et al.
Publicado: (2021)

c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma
por: Huang, YuKun, et al.
Publicado: (2016)

First-in-human uPAR PET: Imaging of Cancer Aggressiveness
por: Persson, Morten, et al.
Publicado: (2015)

[(68)Ga]NODAGA-RGD – Metabolic stability, biodistribution, and dosimetry data from patients with hepatocellular carcinoma and liver cirrhosis
por: Haubner, Roland, et al.
Publicado: (2016)

First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist (68)Ga-NODAGA-MJ9
por: Gnesin, Silvano, et al.
Publicado: (2018)

A Randomized, Factorial Phase II Study to Determine the Optimal Dosing Regimen for (68)Ga-Satoreotide Trizoxetan as an Imaging Agent in Patients with Gastroenteropancreatic Neuroendocrine Tumors
por: Virgolini, Irene, et al.
Publicado: (2022)

In Vivo Imaging of Experimental Melanoma Tumors using the Novel Radiotracer (68)Ga-NODAGA-Procainamide (PCA)
por: Kertész, István, et al.
Publicado: (2017)

Brain Imaging of the GLP-1 Receptor in Obesity Using (68)Ga-NODAGA-Exendin-4 PET
por: Deden, Laura N., et al.
Publicado: (2021)

c(RGDyK)-Decorated Pluronic Micelles for Enhanced Doxorubicin and Paclitaxel Delivery to Brain Glioma [Retraction]
Publicado: (2022)

Comparison of Ga-68-Labeled Fusarinine C-Based Multivalent RGD Conjugates and [(68)Ga]NODAGA-RGD—In Vivo Imaging Studies in Human Xenograft Tumors
por: Zhai, Chuangyan, et al.
Publicado: (2016)

Dual-functional c(RGDyK)-decorated Pluronic micelles designed for antiangiogenesis and the treatment of drug-resistant tumor
por: Chen, Yanzuo, et al.
Publicado: (2015)

PET imaging of (68)Ga-NODAGA-RGD, as compared with (18)F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma
por: Isal, Sibel, et al.
Publicado: (2018)

Synthesis and Anti-Angiogenic Activity of Novel c(RGDyK) Peptide-Based JH-VII-139-1 Conjugates
por: Leonidis, George, et al.
Publicado: (2023)

Imaging angiogenesis in atherosclerosis in large arteries with (68)Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease
por: Dietz, Matthieu, et al.
Publicado: (2021)

In Vivo Biodistribution and Anti-Tumor Efficacy Evaluation of Doxorubicin and Paclitaxel-Loaded Pluronic Micelles Decorated with c(RGDyK) Peptide
por: Chen, Yanzuo, et al.
Publicado: (2016)

(68)Ga-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism
por: Boss, Marti, et al.
Publicado: (2022)

Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective
por: Verma, Priyanka, et al.
Publicado: (2023)

Imaging of α(v)β(3) integrin expression in experimental myocardial ischemia with [(68)Ga]NODAGA-RGD positron emission tomography
por: Grönman, Maria, et al.
Publicado: (2017)

A comparison of three (67/68)Ga-labelled exendin-4 derivatives for β-cell imaging on the GLP-1 receptor: the influence of the conjugation site of NODAGA as chelator
por: Jodal, Andreas, et al.
Publicado: (2014)

Human Dose Assessment of (68)Ga-NODAGA-RGD-BBN Heterodimer Peptide based on Animal Data
por: Amraee, Naeimeh, et al.
Publicado: (2022)

Head and neck tumors angiogenesis imaging with (68)Ga-NODAGA-RGD in comparison to (18)F-FDG PET/CT: a pilot study
por: Durante, Steve, et al.
Publicado: (2020)

PET imaging of an optimized anti-PD-L1 probe (68)Ga-NODAGA-BMS986192 in immunocompetent mice and non-human primates
por: Zhou, Huimin, et al.
Publicado: (2022)

Development and Validation of an Analytical HPLC Method to Assess Chemical and Radiochemical Purity of [(68)Ga]Ga-NODAGA-Exendin-4 Produced by a Fully Automated Method
por: Migliari, Silvia, et al.
Publicado: (2022)

[(68)Ga]Ga-DOTA-TOC: The First FDA-Approved (68)Ga-Radiopharmaceutical for PET Imaging
por: Hennrich, Ute, et al.
Publicado: (2020)

Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using (68)Ga-NODAGA-exendin-4 positron emission tomography
por: Ståhle, Mia, et al.
Publicado: (2018)

Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization
por: Pandya, Darpan N., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ma5tk19vm8mmae3ra780gme4co