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Effect of Moderate Consumption of Different Phenolic-Content Beers on the Human Gut Microbiota Composition: A Randomized Crossover Trial

The moderate consumption of beer has been associated with positive effects on health, and these benefits are driven, in part, by the antioxidant properties of phenolic compounds found in this beverage. However, the potential impact of beer polyphenols on the human gut microbiome and their consequenc...

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Autores principales: Martínez-Montoro, José Ignacio, Quesada-Molina, Mar, Gutiérrez-Repiso, Carolina, Ruiz-Limón, Patricia, Subiri-Verdugo, Alba, Tinahones, Francisco J., Moreno-Indias, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027304/
https://www.ncbi.nlm.nih.gov/pubmed/35453381
http://dx.doi.org/10.3390/antiox11040696
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author Martínez-Montoro, José Ignacio
Quesada-Molina, Mar
Gutiérrez-Repiso, Carolina
Ruiz-Limón, Patricia
Subiri-Verdugo, Alba
Tinahones, Francisco J.
Moreno-Indias, Isabel
author_facet Martínez-Montoro, José Ignacio
Quesada-Molina, Mar
Gutiérrez-Repiso, Carolina
Ruiz-Limón, Patricia
Subiri-Verdugo, Alba
Tinahones, Francisco J.
Moreno-Indias, Isabel
author_sort Martínez-Montoro, José Ignacio
collection PubMed
description The moderate consumption of beer has been associated with positive effects on health, and these benefits are driven, in part, by the antioxidant properties of phenolic compounds found in this beverage. However, the potential impact of beer polyphenols on the human gut microbiome and their consequences are yet to be elucidated. In this study, our aim was to evaluate the effect of three different phenolic-content beers on the gut microbiome and the potential role of the induced shifts in the antioxidant capacity of beer polyphenols. In total, 20 subjects (10 healthy volunteers and 10 individuals with metabolic syndrome) were randomly assigned in a crossover design to consume each of the different beers (alcohol-free, lager or dark beer) during a 2-week intervention. Significant changes in the relative abundance of Streptococcaceae and Streptococcus were found after beer consumption. An increased abundance of Streptococcaceae and Streptococcus was observed after the consumption of dark beer, with no detected differences between baseline and alcohol-free/lager beer intervention. Moreover, some of the detected differences appeared to be related to the metabolic status. Finally, a decrease in porphyrin metabolism and heme biosynthesis was found after the intervention, especially after the consumption of dark beer. These results show that the antioxidant capacity of beer polyphenols may induce positive shifts in gut microbiota composition, and some of the observed changes may also boost the antioxidant capacity of these compounds.
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spelling pubmed-90273042022-04-23 Effect of Moderate Consumption of Different Phenolic-Content Beers on the Human Gut Microbiota Composition: A Randomized Crossover Trial Martínez-Montoro, José Ignacio Quesada-Molina, Mar Gutiérrez-Repiso, Carolina Ruiz-Limón, Patricia Subiri-Verdugo, Alba Tinahones, Francisco J. Moreno-Indias, Isabel Antioxidants (Basel) Article The moderate consumption of beer has been associated with positive effects on health, and these benefits are driven, in part, by the antioxidant properties of phenolic compounds found in this beverage. However, the potential impact of beer polyphenols on the human gut microbiome and their consequences are yet to be elucidated. In this study, our aim was to evaluate the effect of three different phenolic-content beers on the gut microbiome and the potential role of the induced shifts in the antioxidant capacity of beer polyphenols. In total, 20 subjects (10 healthy volunteers and 10 individuals with metabolic syndrome) were randomly assigned in a crossover design to consume each of the different beers (alcohol-free, lager or dark beer) during a 2-week intervention. Significant changes in the relative abundance of Streptococcaceae and Streptococcus were found after beer consumption. An increased abundance of Streptococcaceae and Streptococcus was observed after the consumption of dark beer, with no detected differences between baseline and alcohol-free/lager beer intervention. Moreover, some of the detected differences appeared to be related to the metabolic status. Finally, a decrease in porphyrin metabolism and heme biosynthesis was found after the intervention, especially after the consumption of dark beer. These results show that the antioxidant capacity of beer polyphenols may induce positive shifts in gut microbiota composition, and some of the observed changes may also boost the antioxidant capacity of these compounds. MDPI 2022-03-31 /pmc/articles/PMC9027304/ /pubmed/35453381 http://dx.doi.org/10.3390/antiox11040696 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martínez-Montoro, José Ignacio
Quesada-Molina, Mar
Gutiérrez-Repiso, Carolina
Ruiz-Limón, Patricia
Subiri-Verdugo, Alba
Tinahones, Francisco J.
Moreno-Indias, Isabel
Effect of Moderate Consumption of Different Phenolic-Content Beers on the Human Gut Microbiota Composition: A Randomized Crossover Trial
title Effect of Moderate Consumption of Different Phenolic-Content Beers on the Human Gut Microbiota Composition: A Randomized Crossover Trial
title_full Effect of Moderate Consumption of Different Phenolic-Content Beers on the Human Gut Microbiota Composition: A Randomized Crossover Trial
title_fullStr Effect of Moderate Consumption of Different Phenolic-Content Beers on the Human Gut Microbiota Composition: A Randomized Crossover Trial
title_full_unstemmed Effect of Moderate Consumption of Different Phenolic-Content Beers on the Human Gut Microbiota Composition: A Randomized Crossover Trial
title_short Effect of Moderate Consumption of Different Phenolic-Content Beers on the Human Gut Microbiota Composition: A Randomized Crossover Trial
title_sort effect of moderate consumption of different phenolic-content beers on the human gut microbiota composition: a randomized crossover trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027304/
https://www.ncbi.nlm.nih.gov/pubmed/35453381
http://dx.doi.org/10.3390/antiox11040696
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