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Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction

BACKGROUND: 5-Fluorouracil (5-FU) is a used chemotherapy drug for cancer, and its main side effect is intestinal mucositis which causes chemotherapy to fail. It was known that short-chain fatty acids (SCFAs) can inhibit immune cell release of various proinflammatory factors and inhibit excessive int...

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Detalles Bibliográficos
Autores principales: Yue, Xi, Wen, Sun, Long-kun, Ding, Man, Yan, Chang, Sun, Min, Zhang, Shuang-yu, Li, Xin, Qian, Jie, Ma, Liang, Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027456/
https://www.ncbi.nlm.nih.gov/pubmed/35448938
http://dx.doi.org/10.1186/s12865-022-00495-3