Theratyping of the Rare CFTR Variants E193K and R334W in Rectal Organoid-Derived Epithelial Monolayers

Background: The effect of presently available CFTR modulator combinations, such as elexacaftor (ELX), tezacaftor (TEZ), and ivacaftor (IVA), on rare CFTR alleles is often unknown. Several assays have been developed, such as forskolin-induced swelling (FIS), to evaluate the rescue of such uncommon CF...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciciriello, Fabiana, Bijvelds, Marcel J. C., Alghisi, Federico, Meijsen, Kelly F., Cristiani, Luca, Sorio, Claudio, Melotti, Paola, Fiocchi, Alessandro G., Lucidi, Vincenzina, De Jonge, Hugo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027586/
https://www.ncbi.nlm.nih.gov/pubmed/35455747
http://dx.doi.org/10.3390/jpm12040632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027586/
https://www.ncbi.nlm.nih.gov/pubmed/35455747
http://dx.doi.org/10.3390/jpm12040632

Ejemplares similares