Exclusion of NUMB Exon12 Controls Cancer Cell Migration through Regulation of Notch1-SMAD3 Crosstalk

NUMB is an endocytic adaptor protein that contains four isoforms (p65, p66, p71 and p72) due to alternative splicing regulation. Here, we show that NUMB exon12 (E12)-skipping isoforms p65/p66 promote epithelial to mesenchymal transition (EMT) and cancer cell migration in vitro, and facilitate cancer...

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Detalles Bibliográficos
Autores principales: Zhan, Zheng, Yuan, Ningyang, You, Xue, Meng, Kai, Sha, Rula, Wang, Zhenzhen, Peng, Qian, Xie, Zhiqin, Chen, Ruijiao, Feng, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027642/
https://www.ncbi.nlm.nih.gov/pubmed/35457181
http://dx.doi.org/10.3390/ijms23084363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027642/
https://www.ncbi.nlm.nih.gov/pubmed/35457181
http://dx.doi.org/10.3390/ijms23084363

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