Cargando…

Exclusion of NUMB Exon12 Controls Cancer Cell Migration through Regulation of Notch1-SMAD3 Crosstalk

NUMB is an endocytic adaptor protein that contains four isoforms (p65, p66, p71 and p72) due to alternative splicing regulation. Here, we show that NUMB exon12 (E12)-skipping isoforms p65/p66 promote epithelial to mesenchymal transition (EMT) and cancer cell migration in vitro, and facilitate cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhan, Zheng, Yuan, Ningyang, You, Xue, Meng, Kai, Sha, Rula, Wang, Zhenzhen, Peng, Qian, Xie, Zhiqin, Chen, Ruijiao, Feng, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027642/ https://www.ncbi.nlm.nih.gov/pubmed/35457181 http://dx.doi.org/10.3390/ijms23084363

Ejemplares similares

Single‐Cell RNA Sequencing Reveals Heterogeneity of Myf5‐Derived Cells and Altered Myogenic Fate in the Absence of SRSF2
por: Guo, Ruochen, et al.
Publicado: (2022)

Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2
por: Confalonieri, Stefano, et al.
Publicado: (2019)

NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain
por: Luo, Zhiyuan, et al.
Publicado: (2019)

High levels of Notch signaling down-regulate Numb and Numblike
por: Chapman, Gavin, et al.
Publicado: (2006)

Rewired Notch/p53 by Numb’ing Mdm2
por: Kim, Hyungsoo, et al.
Publicado: (2018)

Expression of Notch1 and Numb in small cell lung cancer
por: Kikuchi, Hajime, et al.
Publicado: (2017)

Splicing Factor SRSF1 Is Essential for Satellite Cell Proliferation and Postnatal Maturation of Neuromuscular Junctions in Mice
por: Liu, Yuguo, et al.
Publicado: (2020)

Aberrant expression of Notch1/numb/snail signaling, an epithelial mesenchymal transition related pathway, in adenomyosis
por: Qi, Shasha, et al.
Publicado: (2015)

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
por: Pece, Salvatore, et al.
Publicado: (2004)

Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling
por: Bocci, Federico, et al.
Publicado: (2017)

The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis
por: Miao, Lianjie, et al.
Publicado: (2021)

Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling
por: Shu, Yuke, et al.
Publicado: (2021)

The role of NUMB/NUMB isoforms in cancer stem cells
por: Choi, Hye Yeon, et al.
Publicado: (2021)

Nandrolone‐induced nuclear accumulation of MyoD protein is mediated by Numb, a Notch inhibitor, in C2C12 myoblasts
por: Liu, Xin‐Hua, et al.
Publicado: (2018)

Loss of nuclear NOTCH1, but not its negative regulator NUMB, is an independent predictor of cervical malignancy
por: Vázquez-Ulloa, Elenaé, et al.
Publicado: (2018)

PTBP1 promotes hepatocellular carcinoma progression by regulating the skipping of exon 9 in NUMB pre-mRNA
por: He, Zhentao, et al.
Publicado: (2023)

Numb Independently Antagonizes Sanpodo Membrane Targeting and Notch Signaling in Drosophila Sensory Organ Precursor Cells
por: Tong, Xin, et al.
Publicado: (2010)

Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear
por: Eddison, Mark, et al.
Publicado: (2015)

Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells
por: Johnson, Seth A., et al.
Publicado: (2016)

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
por: Zhang, Jianchao, et al.
Publicado: (2016)

Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study
por: Gonulcu, Sinem Cil, et al.
Publicado: (2020)

Numb Is an Endocytic Protein
por: Santolini, Elisa, et al.
Publicado: (2000)

The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer
por: Harbuzariu, Adriana, et al.
Publicado: (2018)

Biological impact of mutually exclusive exon switching
por: Lam, Su Datt, et al.
Publicado: (2021)

Why is That Chin Numb? A Case of Burkitt’s Lymphoma Presenting as Numb Chin Syndrome
por: Neel, Sejal, et al.
Publicado: (2020)

Expression and Function of NUMB in Odontogenesis
por: Li, Haitao, et al.
Publicado: (2013)

A Man with Numbness in the Hands
por: Tongprasert, Siam, et al.
Publicado: (2018)

A Man with Numbness in the Hands
por: Tongprasert, Siam, et al.
Publicado: (2019)

Progressive lip numbness due to numb chin and cheek syndrome in a patient with prostate cancer
por: Rabadi, Meheroz H.
Publicado: (2020)

MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy
por: Li, Meng-Ran, et al.
Publicado: (2022)

Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology
por: Pillmann, Holger, et al.
Publicado: (2011)

A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer
por: Colaluca, Ivan Nicola, et al.
Publicado: (2018)

Numb Protects Renal Proximal Tubular Cells from Puromycin Aminonucleoside-Induced Apoptosis through Inhibiting Notch Signaling Pathway
por: Ding, Xuebing, et al.
Publicado: (2011)

Numb and Alzheimer’s Disease: The Current Picture
por: Ntelios, Dimitrios, et al.
Publicado: (2012)

NUMB and NUMBL differences in gene regulation
por: García-Heredia, José Manuel, et al.
Publicado: (2018)

Female with left‐sided numbness and weakness
por: Gately, Shane C., et al.
Publicado: (2022)

NUMB as a Therapeutic Target for Melanoma
por: Hristova, Denitsa M., et al.
Publicado: (2022)

The Relationship between Numbness and Quality of Life
por: Nagai, Shuhei, et al.
Publicado: (2023)

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
por: García-Heredia, José M., et al.
Publicado: (2016)

An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion
por: Collins, Katherine M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_m612leg1hbahja2mf9s3fosgvf