Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis

6-Mercaptopurine (6-MP) is a cornerstone of the maintenance regimen for pediatric acute lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphatase (ITPA) is considered a candidate pharmacogenetic marker that may affect metabolism and 6-MP-induced toxicities; however, the findings are inconsi...

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Detalles Bibliográficos
Autores principales: Lee, Yeonhong, Jang, Eun Jeong, Yoon, Ha-Young, Yee, Jeong, Gwak, Hye-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027773/
https://www.ncbi.nlm.nih.gov/pubmed/35455413
http://dx.doi.org/10.3390/ph15040416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027773/
https://www.ncbi.nlm.nih.gov/pubmed/35455413
http://dx.doi.org/10.3390/ph15040416

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