Cargando…

Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis

6-Mercaptopurine (6-MP) is a cornerstone of the maintenance regimen for pediatric acute lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphatase (ITPA) is considered a candidate pharmacogenetic marker that may affect metabolism and 6-MP-induced toxicities; however, the findings are inconsi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Yeonhong, Jang, Eun Jeong, Yoon, Ha-Young, Yee, Jeong, Gwak, Hye-Sun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Systematic Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027773/ https://www.ncbi.nlm.nih.gov/pubmed/35455413 http://dx.doi.org/10.3390/ph15040416

Ejemplares similares

Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia
por: Farfan, Mauricio J, et al.
Publicado: (2014)

The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia
por: Lee, Jae Min, et al.
Publicado: (2021)

ITPA, TPMT, and NUDT15 Genetic Polymorphisms Predict 6-Mercaptopurine Toxicity in Middle Eastern Children With Acute Lymphoblastic Leukemia
por: Moradveisi, Borhan, et al.
Publicado: (2019)

Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China
por: Mao, Xiaoyan, et al.
Publicado: (2021)

ITPA Polymorphisms and the Incidence of Toxicities in Children with Acute Lymphoblastic Leukemia
por: Svasdisant, Patpetra, et al.
Publicado: (2023)

Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
por: Zhou, Hong, et al.
Publicado: (2018)

Variants in TPMT, ITPA, ABCC4 and ABCB1 Genes As Predictors of 6-mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia
por: Milosevic, Goran, et al.
Publicado: (2018)

Pharmacogenetic Analysis of Pediatric Patients with Acute Lymphoblastic Leukemia: A Possible Association between Survival Rate and ITPA Polymorphism
por: Kim, Hyery, et al.
Publicado: (2012)

ITPA:c.94C>A and NUDT15:c.415C>T Polymorphisms and Their Relation to Mercaptopurine-Related Myelotoxicity in Childhood Leukemia in Thailand
por: Boonyawat, Boonchai, et al.
Publicado: (2021)

APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia
por: Kim, Hyery, et al.
Publicado: (2018)

Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia
por: Alsous, Mervat, et al.
Publicado: (2017)

Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia
por: Zhang, Melissa, et al.
Publicado: (2019)

The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia
por: Nguyen, Mai-Lan, et al.
Publicado: (2023)

The rs1127354 Polymorphism in ITPA Is Associated with Susceptibility to Infertility
por: Mollaahmadi, Fahimeh, et al.
Publicado: (2018)

Mercaptopurine/Methotrexate Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia: Clinical Facts and Fiction
por: Schmiegelow, Kjeld, et al.
Publicado: (2014)

Use of Allopurinol to Mitigate 6-Mercaptopurine Associated Gastrointestinal Toxicity in Acute Lymphoblastic Leukemia
por: Conneely, Shannon E., et al.
Publicado: (2020)

Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia
por: Cao, Minyuan, et al.
Publicado: (2020)

Association of ITPA Genotype with Event-Free Survival and Relapse Rates in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy
por: Smid, Alenka, et al.
Publicado: (2014)

Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients
por: Park, Yoomi, et al.
Publicado: (2019)

Association between CYP3A5 Polymorphism and Statin-Induced Adverse Events: A Systemic Review and Meta-Analysis
por: Yee, Jeong, et al.
Publicado: (2021)

Childhood lymphoblastic leukaemia: sex difference in 6-mercaptopurine utilization.
por: Lilleyman, J. S., et al.
Publicado: (1984)

Severe recurrent nocturnal hypoglycemia during chemotherapy with 6-mercaptopurine in a child with acute lymphoblastic leukemia
por: Cho, Eun Mi, et al.
Publicado: (2018)

The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis
por: Yee, Jeong, et al.
Publicado: (2020)

Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia
por: Ali, Awol Mekonnen, et al.
Publicado: (2023)

Associations of GNAS and RGS Gene Polymorphisms with the Risk of Ritodrine-Induced Adverse Events in Korean Women with Preterm Labor: A Cohort Study
por: Jang, Eun-Jeong, et al.
Publicado: (2022)

Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia
por: Zou, Yaru, et al.
Publicado: (2021)

TPMT*3C as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic Leukemia
por: Jantararoungtong, Thawinee, et al.
Publicado: (2021)

Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review
por: Zeckanovic, Aida, et al.
Publicado: (2023)

An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia
por: Tanaka, Yoichi, et al.
Publicado: (2021)

Effects of CYP2B6 polymorphisms on plasma nevirapine concentrations: a systematic review and meta-analysis
por: Yoon, Ha Young, et al.
Publicado: (2020)

Association between Genetic Polymorphisms and Bleeding in Patients on Direct Oral Anticoagulants
por: Yoon, Ha-Young, et al.
Publicado: (2022)

Allopurinol use during pediatric acute lymphoblastic leukemia maintenance therapy safely corrects skewed 6-mercaptopurine metabolism, improving inadequate myelosuppression and reducing gastrointestinal toxicity
por: Cohen, Gordon, et al.
Publicado: (2020)

Risk factors of opioid-induced adverse reactions in elderly male outpatients of Korea Veterans Hospital
por: Kim, Ji Young, et al.
Publicado: (2018)

ITPA Polymorphisms Are Associated with Hematological Side Effects during Antiviral Therapy for Chronic HCV Infection
por: Maan, Raoel, et al.
Publicado: (2015)

Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?
por: Lennard, L., et al.
Publicado: (1993)

Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: a possible indicator of non-compliance?
por: Lennard, L., et al.
Publicado: (1995)

ITPA Related Developmental Encephalopathy: Key Role of Neuroimaging
por: Çavuşoğlu, Dilek, et al.
Publicado: (2022)

Incidence and determinants of hematotoxicity in acute lymphoblastic leukemia children who received 6-mercaptopurine based maintenance therapy in Addis Ababa, Ethiopia
por: Ali, Awol Mekonnen, et al.
Publicado: (2023)

Oral Maintenance Chemotherapy with 6-Mercaptopurine and Methotrexate in Patients with Acute Myeloid Leukemia Ineligible for Transplantation
por: Choi, Yong Won, et al.
Publicado: (2015)

Association of P450 Oxidoreductase Gene Polymorphism with Tacrolimus Pharmacokinetics in Renal Transplant Recipients: A Systematic Review and Meta-Analysis
por: Lee, Da-Hoon, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n2e5s5u5d2aqogh224h4q65ucp