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AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis

A relationship between an acidic pH in the joints, osteoarthritis (OA), and pain has been previously demonstrated. Acidosis Chemical Exchange Saturation Transfer (acidoCEST) indirectly measures the extracellular pH through the assessment of the exchange of protons between amide groups on iodinated c...

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Autores principales: Lombardi, Alecio F., Ma, Yajun, Jang, Hyungseok, Jerban, Saeed, Tang, Qingbo, Searleman, Adam C., Meyer, Robert Scott, Du, Jiang, Chang, Eric Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027981/
https://www.ncbi.nlm.nih.gov/pubmed/35457284
http://dx.doi.org/10.3390/ijms23084466
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author Lombardi, Alecio F.
Ma, Yajun
Jang, Hyungseok
Jerban, Saeed
Tang, Qingbo
Searleman, Adam C.
Meyer, Robert Scott
Du, Jiang
Chang, Eric Y.
author_facet Lombardi, Alecio F.
Ma, Yajun
Jang, Hyungseok
Jerban, Saeed
Tang, Qingbo
Searleman, Adam C.
Meyer, Robert Scott
Du, Jiang
Chang, Eric Y.
author_sort Lombardi, Alecio F.
collection PubMed
description A relationship between an acidic pH in the joints, osteoarthritis (OA), and pain has been previously demonstrated. Acidosis Chemical Exchange Saturation Transfer (acidoCEST) indirectly measures the extracellular pH through the assessment of the exchange of protons between amide groups on iodinated contrast agents and bulk water. It is possible to estimate the extracellular pH in the osteoarthritic joint using acidoCEST MRI. However, conventional MR sequences cannot image deep layers of cartilage, meniscus, ligaments, and other musculoskeletal tissues that present with short echo time and fast signal decay. Ultrashort echo time (UTE) MRI, on the other hand, has been used successfully to image those joint tissues. Here, our goal is to compare the pH measured in the knee joints of volunteers without OA and patients with severe OA using acidoCEST-UTE MRI. Patients without knee OA and patients with severe OA were examined using acidoCEST-UTE MRI and the mean pH of cartilage, meniscus, and fluid was calculated. Additionally, the relationship between the pH measurements and the Knee Injury and Osteoarthritis Outcome Score (KOOS) was investigated. AcidoCEST-UTE MRI can detect significant differences in the pH of knee cartilage, meniscus, and fluid between joints without and with OA, with OA showing lower pH values. In addition, symptoms and knee-joint function become worse at lower pH measurements.
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spelling pubmed-90279812022-04-23 AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis Lombardi, Alecio F. Ma, Yajun Jang, Hyungseok Jerban, Saeed Tang, Qingbo Searleman, Adam C. Meyer, Robert Scott Du, Jiang Chang, Eric Y. Int J Mol Sci Article A relationship between an acidic pH in the joints, osteoarthritis (OA), and pain has been previously demonstrated. Acidosis Chemical Exchange Saturation Transfer (acidoCEST) indirectly measures the extracellular pH through the assessment of the exchange of protons between amide groups on iodinated contrast agents and bulk water. It is possible to estimate the extracellular pH in the osteoarthritic joint using acidoCEST MRI. However, conventional MR sequences cannot image deep layers of cartilage, meniscus, ligaments, and other musculoskeletal tissues that present with short echo time and fast signal decay. Ultrashort echo time (UTE) MRI, on the other hand, has been used successfully to image those joint tissues. Here, our goal is to compare the pH measured in the knee joints of volunteers without OA and patients with severe OA using acidoCEST-UTE MRI. Patients without knee OA and patients with severe OA were examined using acidoCEST-UTE MRI and the mean pH of cartilage, meniscus, and fluid was calculated. Additionally, the relationship between the pH measurements and the Knee Injury and Osteoarthritis Outcome Score (KOOS) was investigated. AcidoCEST-UTE MRI can detect significant differences in the pH of knee cartilage, meniscus, and fluid between joints without and with OA, with OA showing lower pH values. In addition, symptoms and knee-joint function become worse at lower pH measurements. MDPI 2022-04-18 /pmc/articles/PMC9027981/ /pubmed/35457284 http://dx.doi.org/10.3390/ijms23084466 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lombardi, Alecio F.
Ma, Yajun
Jang, Hyungseok
Jerban, Saeed
Tang, Qingbo
Searleman, Adam C.
Meyer, Robert Scott
Du, Jiang
Chang, Eric Y.
AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis
title AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis
title_full AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis
title_fullStr AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis
title_full_unstemmed AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis
title_short AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis
title_sort acidocest-ute mri reveals an acidic microenvironment in knee osteoarthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027981/
https://www.ncbi.nlm.nih.gov/pubmed/35457284
http://dx.doi.org/10.3390/ijms23084466
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