Leptin Receptor Deficiency Results in Hyperphagia and Increased Fatty Acid Mobilization during Fasting in Rainbow Trout (Oncorhynchus mykiss)

Leptin is a pleiotropic hormone known for regulating appetite and metabolism. To characterize the role of leptin signaling in rainbow trout, we used CRISPR/Cas9 genome editing to disrupt the leptin receptor (LepR) genes, lepra1 and lepra2. We compared wildtype (WT) and mutant fish that were either f...

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Detalles Bibliográficos
Autores principales: Mankiewicz, Jamie L., Picklo, Matthew J., Idso, Joseph, Cleveland, Beth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028016/
https://www.ncbi.nlm.nih.gov/pubmed/35454105
http://dx.doi.org/10.3390/biom12040516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028016/
https://www.ncbi.nlm.nih.gov/pubmed/35454105
http://dx.doi.org/10.3390/biom12040516

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