Cargando…

NLRP3 Inhibition Reduces rt-PA Induced Endothelial Dysfunction under Ischemic Conditions

Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a mainstay of acute ischemic stroke treatment but is associated with bleeding complications, especially after prolonged large vessel occlusion. Recently, inhibition of the NLRP3 inflammasome led to preserved blood–brain barrier (B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bellut, Maximilian, Raimondi, Anthony T., Haarmann, Axel, Zimmermann, Lena, Stoll, Guido, Schuhmann, Michael K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028140/ https://www.ncbi.nlm.nih.gov/pubmed/35453512 http://dx.doi.org/10.3390/biomedicines10040762

Ejemplares similares

NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood–brain barrier integrity in murine stroke
por: Bellut, Maximilian, et al.
Publicado: (2021)

Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice
por: Bellut, Maximilian, et al.
Publicado: (2023)

Regulation and Release of Vasoactive Endoglin by Brain Endothelium in Response to Hypoxia/Reoxygenation in Stroke
por: Haarmann, Axel, et al.
Publicado: (2022)

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice
por: Schuhmann, Michael K., et al.
Publicado: (2019)

Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown
por: Haarmann, Axel, et al.
Publicado: (2019)

rt‐PA with remote ischemic postconditioning for acute ischemic stroke
por: Che, Ruiwen, et al.
Publicado: (2019)

Dimethyl Fumarate Attenuates Lymphocyte Infiltration and Reduces Infarct Size in Experimental Stroke
por: Schuhmann, Michael K., et al.
Publicado: (2023)

Combination treatment with U0126 and rt-PA prevents adverse effects of the delayed rt-PA treatment after acute ischemic stroke
por: Orset, Cyrille, et al.
Publicado: (2021)

Defining cerebral leukocyte populations in local ischemic blood samples from patients with hyperacute stroke
por: Zimmermann, Lena, et al.
Publicado: (2022)

Cognitive deficits in acute mild ischemic stroke and TIA and effects of rt‐PA
por: Rosenbaum Halevi, David, et al.
Publicado: (2019)

Blockade of Platelet Glycoprotein Ibα Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion
por: Bieber, Michael, et al.
Publicado: (2022)

Validity and Efficacy of Methods to Define Blood Brain Barrier Integrity in Experimental Ischemic Strokes: A Comparison of Albumin Western Blot, IgG Western Blot and Albumin Immunofluorescence
por: Franke, Maximilian, et al.
Publicado: (2021)

Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke
por: Sivanandy, Palanisamy, et al.
Publicado: (2011)

Activation of blood coagulation and thrombin generation in acute ischemic stroke treated with rtPA
por: Goldman, Sarah, et al.
Publicado: (2017)

Platelet microparticles: a biomarker for recanalization in rtPA‐treated ischemic stroke patients
por: Bivard, Andrew, et al.
Publicado: (2017)

NLRP3 inflammasome in endothelial dysfunction
por: Bai, Baochen, et al.
Publicado: (2020)

Retinal safety of intravitreal rtPA in healthy rats and under excitotoxic conditions
por: Daruich, Alejandra, et al.
Publicado: (2016)

Enhanced Cerebroprotection of Xenon-Loaded Liposomes in Combination with rtPA Thrombolysis for Embolic Ischemic Stroke
por: Peng, Tao, et al.
Publicado: (2023)

Vasoactive Soluble Endoglin: A Novel Biomarker Indicative of Reperfusion after Cerebral Large-Vessel Occlusion
por: Haarmann, Axel, et al.
Publicado: (2023)

Efficacy of Rosuvastatin Combined with rt-PA Intravenous Thrombolytic Therapy for Elderly Acute Ischemic Stroke Patients
por: Zhu, Jianzhong, et al.
Publicado: (2022)

Successful systemic thrombolysis with rtPA in a patient with history of a life-threatening rtPA-associated orolingual angioedema
por: Pelz, Johann Otto, et al.
Publicado: (2017)

Hyperacute ischemic stroke without lesions on diffusion-weighted imaging in a patient treated with rtPA thrombolysis
por: Jing, Zhen, et al.
Publicado: (2014)

Meta-analysis of Vascular Imaging Features to Predict Outcome Following Intravenous rtPA for Acute Ischemic Stroke
por: Nogueira, Ricardo C., et al.
Publicado: (2016)

Intravenous rtPA versus mechanical thrombectomy in acute ischemic stroke: A historical cohort in Joinville, Brazil
por: Cabral, Norberto L., et al.
Publicado: (2016)

Elevated Serum Lactate Dehydrogenase Predicts Unfavorable Outcomes After rt-PA Thrombolysis in Ischemic Stroke Patients
por: Jin, Huijuan, et al.
Publicado: (2022)

Retracted: Efficacy of Rosuvastatin Combined with rt-PA Intravenous Thrombolytic Therapy for Elderly Acute Ischemic Stroke Patients
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Evaluation of Soluble Junctional Adhesion Molecule-A as a Biomarker of Human Brain Endothelial Barrier Breakdown
por: Haarmann, Axel, et al.
Publicado: (2010)

Efficacy and Safety of Intravenous rtPA in Ischemic Strokes Due to Small-Vessel Occlusion: Systematic Review and Meta-Analysis
por: Karaszewski, Bartosz, et al.
Publicado: (2021)

The Utility of Automated ASPECTS in Acute Ischemic Stroke for Intravenous Recombinant Tissue Plasminogen Activator (IV-rtPA) Therapy
por: Shibata, Soichiro, et al.
Publicado: (2022)

Persistent trigeminal artery in a patient with posterior circulation stroke treated with rt-PA: case report
por: Ferreira, Axel, et al.
Publicado: (2019)

Intrahematomal Ultrasound Enhances RtPA-Fibrinolysis in a Porcine Model of Intracerebral Hemorrhage
por: Masomi-Bornwasser, Julia, et al.
Publicado: (2021)

Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke
por: Schuhmann, Michael K., et al.
Publicado: (2017)

A randomised controlled trial of antiplatelet therapy in combination with Rt-PA thrombolysis in ischemic stroke: rationale and design of the ARTIS-Trial
por: Zinkstok, SM, et al.
Publicado: (2010)

Association Between the Change of Coagulation Parameters and Clinical Prognosis in Acute Ischemic Stroke Patients After Intravenous Thrombolysis With rt-PA
por: Wang, Yu, et al.
Publicado: (2021)

Analysis of influencing factors of early neurological improvement after intravenous rt-PA thrombolysis in acute anterior circulation ischemic stroke
por: Xiufu, Zhang, et al.
Publicado: (2022)

Prognostic Values of Prothrombin Time and Inflammation-Related Parameter in Acute Ischemic Stroke Patients After Intravenous Thrombolysis with rt-PA
por: Zhao, Jingru, et al.
Publicado: (2023)

Infarct growth precedes cerebral thrombosis following experimental stroke in mice
por: Göb, Vanessa, et al.
Publicado: (2021)

A User's Guide to the NINDS rt-PA Stroke Trial Database
por: Dachs, Robert J, et al.
Publicado: (2008)

Does the sex of acute stroke patients influence the effectiveness of rt-PA?
por: Al-hussain, Fawaz, et al.
Publicado: (2014)

Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes
por: Bader, Kenneth B., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_u61kaoj665s5t95ssgmkg41h96