Optimization of a Cefuroxime Axetil-Loaded Liquid Self-Nanoemulsifying Drug Delivery System: Enhanced Solubility, Dissolution and Caco-2 Cell Uptake

Cefuroxime axetil (CA) is an oral cephalosporin which hydrolyzes rapidly to the active parent compound cefuroxime. CA is known to have incomplete oral bioavailability (30–50%) due to its poor solubility and enzymatic conversion to cefuroxime in the gut lumen. In order to overcome these drawbacks, a...

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Detalles Bibliográficos
Autores principales: Khan, Arshad Ali, Atiya, Akhtar, Akhtar, Safia, Yadav, Yogesh, Qureshi, Kamal A., Jaremko, Mariusz, Mahmood, Syed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028143/
https://www.ncbi.nlm.nih.gov/pubmed/35456606
http://dx.doi.org/10.3390/pharmaceutics14040772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028143/
https://www.ncbi.nlm.nih.gov/pubmed/35456606
http://dx.doi.org/10.3390/pharmaceutics14040772

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