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Optimization of a Cefuroxime Axetil-Loaded Liquid Self-Nanoemulsifying Drug Delivery System: Enhanced Solubility, Dissolution and Caco-2 Cell Uptake
Cefuroxime axetil (CA) is an oral cephalosporin which hydrolyzes rapidly to the active parent compound cefuroxime. CA is known to have incomplete oral bioavailability (30–50%) due to its poor solubility and enzymatic conversion to cefuroxime in the gut lumen. In order to overcome these drawbacks, a...
Autores principales: | Khan, Arshad Ali, Atiya, Akhtar, Akhtar, Safia, Yadav, Yogesh, Qureshi, Kamal A., Jaremko, Mariusz, Mahmood, Syed |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028143/ https://www.ncbi.nlm.nih.gov/pubmed/35456606 http://dx.doi.org/10.3390/pharmaceutics14040772 |
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