Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model

Immobilizing antifungal polyenes such as nystatin (Nys) and amphotericin B (AmB) into biodegradable formulations is advantageous compared to free drug administration providing sustained release, reduced dosing due to localized targeting and overall reduced systemic drug toxicity. In this study, we e...

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Detalles Bibliográficos
Autores principales: Pavic, Aleksandar, Stojanovic, Zoran, Pekmezovic, Marina, Veljović, Đorđe, O’Connor, Kevin, Malagurski, Ivana, Nikodinovic-Runic, Jasmina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028145/
https://www.ncbi.nlm.nih.gov/pubmed/35456530
http://dx.doi.org/10.3390/pharmaceutics14040696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028145/
https://www.ncbi.nlm.nih.gov/pubmed/35456530
http://dx.doi.org/10.3390/pharmaceutics14040696

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