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Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation

It is known that the development of foci of chronic inflammation usually accompanies body aging. In these foci, senescent cells appear with a pro-inflammatory phenotype that helps maintain inflammation. Their removal with the help of senolytics significantly improves the general condition of the bod...

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Autores principales: Yegorov, Yegor E., Poznyak, Anastasia V., Bezsonov, Evgeny E., Zhuravlev, Alexander D., Nikiforov, Nikita G., Vishnyakova, Khava S., Orekhov, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028317/
https://www.ncbi.nlm.nih.gov/pubmed/35453534
http://dx.doi.org/10.3390/biomedicines10040782
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author Yegorov, Yegor E.
Poznyak, Anastasia V.
Bezsonov, Evgeny E.
Zhuravlev, Alexander D.
Nikiforov, Nikita G.
Vishnyakova, Khava S.
Orekhov, Alexander N.
author_facet Yegorov, Yegor E.
Poznyak, Anastasia V.
Bezsonov, Evgeny E.
Zhuravlev, Alexander D.
Nikiforov, Nikita G.
Vishnyakova, Khava S.
Orekhov, Alexander N.
author_sort Yegorov, Yegor E.
collection PubMed
description It is known that the development of foci of chronic inflammation usually accompanies body aging. In these foci, senescent cells appear with a pro-inflammatory phenotype that helps maintain inflammation. Their removal with the help of senolytics significantly improves the general condition of the body and, according to many indicators, contributes to rejuvenation. The cells of the immune system participate in the initiation, development, and resolution of inflammation. With age, the human body accumulates mutations, including the cells of the bone marrow, giving rise to the cells of the immune system. We assume that a number of such mutations formed with age can lead to the appearance of “naive” cells with an initially pro-inflammatory phenotype, the migration of which to preexisting foci of inflammation contributes not to the resolution of inflammation but its chronicity. One of such cell variants are monocytes carrying mitochondrial mutations, which may be responsible for comorbidity and deterioration in the prognosis of the course of pathologies associated with aging, such as atherosclerosis, arthritis, osteoporosis, and neurodegenerative diseases.
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spelling pubmed-90283172022-04-23 Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation Yegorov, Yegor E. Poznyak, Anastasia V. Bezsonov, Evgeny E. Zhuravlev, Alexander D. Nikiforov, Nikita G. Vishnyakova, Khava S. Orekhov, Alexander N. Biomedicines Review It is known that the development of foci of chronic inflammation usually accompanies body aging. In these foci, senescent cells appear with a pro-inflammatory phenotype that helps maintain inflammation. Their removal with the help of senolytics significantly improves the general condition of the body and, according to many indicators, contributes to rejuvenation. The cells of the immune system participate in the initiation, development, and resolution of inflammation. With age, the human body accumulates mutations, including the cells of the bone marrow, giving rise to the cells of the immune system. We assume that a number of such mutations formed with age can lead to the appearance of “naive” cells with an initially pro-inflammatory phenotype, the migration of which to preexisting foci of inflammation contributes not to the resolution of inflammation but its chronicity. One of such cell variants are monocytes carrying mitochondrial mutations, which may be responsible for comorbidity and deterioration in the prognosis of the course of pathologies associated with aging, such as atherosclerosis, arthritis, osteoporosis, and neurodegenerative diseases. MDPI 2022-03-27 /pmc/articles/PMC9028317/ /pubmed/35453534 http://dx.doi.org/10.3390/biomedicines10040782 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yegorov, Yegor E.
Poznyak, Anastasia V.
Bezsonov, Evgeny E.
Zhuravlev, Alexander D.
Nikiforov, Nikita G.
Vishnyakova, Khava S.
Orekhov, Alexander N.
Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation
title Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation
title_full Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation
title_fullStr Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation
title_full_unstemmed Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation
title_short Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation
title_sort somatic mutations of hematopoietic cells are an additional mechanism of body aging, conducive to comorbidity and increasing chronification of inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028317/
https://www.ncbi.nlm.nih.gov/pubmed/35453534
http://dx.doi.org/10.3390/biomedicines10040782
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