Cargando…

A Monoclonal Anti-HMGB1 Antibody Attenuates Neurodegeneration in an Experimental Animal Model of Glaucoma

Neuroinflammation is a crucial process for the loss of retinal ganglion cells (RGC), a major characteristic of glaucoma. High expression of high-mobility group box protein 1 (HMGB1) plays a detrimental role in inflammatory processes and is elevated in the retinas of glaucoma patients. Therefore, thi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tonner, Henrik, Hunn, Selina, Auler, Nadine, Schmelter, Carsten, Beutgen, Vanessa M., von Pein, Harald D., Pfeiffer, Norbert, Grus, Franz H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028318/ https://www.ncbi.nlm.nih.gov/pubmed/35456925 http://dx.doi.org/10.3390/ijms23084107

Ejemplares similares

Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma
por: Tonner, Henrik, et al.
Publicado: (2022)

Autoantigens in the trabecular meshwork and glaucoma‐specific alterations in the natural autoantibody repertoire
por: Beutgen, Vanessa M, et al.
Publicado: (2020)

Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways
por: Auler, Nadine, et al.
Publicado: (2021)

Contribution of the Commensal Microflora to the Immunological Homeostasis and the Importance of Immune-Related Drug Development for Clinical Applications
por: Beutgen, Vanessa M., et al.
Publicado: (2021)

Serological Levels of Anti-clathrin Antibodies Are Decreased in Patients With Pseudoexfoliation Glaucoma
por: Beutgen, Vanessa M., et al.
Publicado: (2021)

Autoantibody Biomarker Discovery in Primary Open Angle Glaucoma Using Serological Proteome Analysis (SERPA)
por: Beutgen, Vanessa M., et al.
Publicado: (2019)

Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein histone H3.1
por: Fomo, Kristian Nzogang, et al.
Publicado: (2022)

An In-Depth View of the Porcine Trabecular Meshwork Proteome
por: Funke, Sebastian, et al.
Publicado: (2019)

Synthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy
por: Schmelter, Carsten, et al.
Publicado: (2019)

Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model
por: Teister, J., et al.
Publicado: (2017)

Glaucoma related Proteomic Alterations in Human Retina Samples
por: Funke, Sebastian, et al.
Publicado: (2016)

Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Networks in Retinal Tissues
por: Schmelter, Carsten, et al.
Publicado: (2021)

Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma
por: Gramlich, Oliver W., et al.
Publicado: (2016)

Lectin-Based Affinity Enrichment and Characterization of N-Glycoproteins from Human Tear Film by Mass Spectrometry
por: Schmelter, Carsten, et al.
Publicado: (2023)

Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma
por: Anders, Fabian, et al.
Publicado: (2017)

Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A)
por: Schmelter, Carsten, et al.
Publicado: (2023)

Comparison of Two Solid-Phase Extraction (SPE) Methods for the Identification and Quantification of Porcine Retinal Protein Markers by LC-MS/MS
por: Schmelter, Carsten, et al.
Publicado: (2018)

Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells
por: Bell, Katharina, et al.
Publicado: (2012)

Comparative Quantitative Analysis of Porcine Optic Nerve Head and Retina Subproteomes
por: Funke, Sebastian, et al.
Publicado: (2019)

Modulation of the Immune System for the Treatment of Glaucoma
por: Bell, Katharina, et al.
Publicado: (2018)

Longitudinal Analysis of Serum Autoantibody-Reactivities in Patients with Primary Open Angle Glaucoma and Optic Disc Hemorrhage
por: Lorenz, Katrin, et al.
Publicado: (2016)

Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma
por: Lauzi, Jasmin, et al.
Publicado: (2019)

Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina
por: Gramlich, Oliver W., et al.
Publicado: (2013)

Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmune glaucoma
por: Joachim, Stephanie C., et al.
Publicado: (2013)

Retinal Ganglion Cell Loss Is Accompanied by Antibody Depositions and Increased Levels of Microglia after Immunization with Retinal Antigens
por: Joachim, Stephanie C., et al.
Publicado: (2012)

Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS)
por: Korb, Christina A., et al.
Publicado: (2023)

The Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model
por: Anders, Fabian, et al.
Publicado: (2017)

Neurodegeneration and Neuroprotection in Glaucoma
por: Gauthier, Angela C., et al.
Publicado: (2016)

Glaucoma as Neurodegeneration in the Brain
por: Chan, Jane W, et al.
Publicado: (2021)

Intraocular pressure and ocular pulse amplitude using dynamic contour tonometry and contact lens tonometry
por: Hoffmann, Esther M, et al.
Publicado: (2004)

Age related retinal Ganglion cell susceptibility in context of autophagy deficiency
por: Bell, Katharina, et al.
Publicado: (2020)

Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients
por: Perumal, Natarajan, et al.
Publicado: (2016)

Oral Microbiome Link to Neurodegeneration in Glaucoma
por: Astafurov, Konstantin, et al.
Publicado: (2014)

Microglia alterations predict neurodegeneration in glaucoma
Publicado: (2015)

T Cell-Mediated Autoimmunity in Glaucoma Neurodegeneration
por: Wang, Lixiang, et al.
Publicado: (2021)

Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway
por: Bell, Katharina, et al.
Publicado: (2015)

First insight into the proteome landscape of the porcine short posterior ciliary arteries: Key signalling pathways maintaining physiologic functions
por: Manicam, Caroline, et al.
Publicado: (2016)

Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients
por: Bell, Katharina, et al.
Publicado: (2020)

Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma
por: Duarte, Joao N.
Publicado: (2021)

Transthyretin and complex protein pattern in aqueous humor of patients with primary open-angle glaucoma
por: Grus, F. H., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_28c696s3rhpf8gfvt3bpnh8go9