The Influence of the CES1 Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension

The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1). Previous studies show that variant rs71647871 in the CES1 gene affects the pharmacokinetics of enalapril on liver samples as well as healthy volunteer...

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Detalles Bibliográficos
Autores principales: Ikonnikova, Anna, Rodina, Tatiana, Dmitriev, Artem, Melnikov, Evgeniy, Kazakov, Ruslan, Nasedkina, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028383/
https://www.ncbi.nlm.nih.gov/pubmed/35455696
http://dx.doi.org/10.3390/jpm12040580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028383/
https://www.ncbi.nlm.nih.gov/pubmed/35455696
http://dx.doi.org/10.3390/jpm12040580

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