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Pharmacokinetic Imaging Using (99m)Tc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats
Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. (99m)Tc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. (99m)Tc-mebrofenin imaging was...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028474/ https://www.ncbi.nlm.nih.gov/pubmed/35455390 http://dx.doi.org/10.3390/ph15040392 |