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Pharmacokinetic Imaging Using (99m)Tc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. (99m)Tc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. (99m)Tc-mebrofenin imaging was...

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Detalles Bibliográficos
Autores principales:	Marie, Solène, Hernández-Lozano, Irene, Le Vée, Marc, Breuil, Louise, Saba, Wadad, Goislard, Maud, Goutal, Sébastien, Truillet, Charles, Langer, Oliver, Fardel, Olivier, Tournier, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028474/ https://www.ncbi.nlm.nih.gov/pubmed/35455390 http://dx.doi.org/10.3390/ph15040392

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