Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Microvascular thrombosis in patients with thrombotic thrombocytopenic purpura (TTP) is initiated by GPIbα-mediated platelet binding to von Willebrand factor (VWF). Binding of VWF to GPIbα causes activation of the platelet surface integrin αIIbβ3. However, the mechanism of GPIbα-initiated activation...

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Detalles Bibliográficos
Autores principales: Shao, Bojing, Hoover, Christopher, Shi, Huiping, Kondo, Yuji, Lee, Robert H., Chen, Junmei, Shan, Xindi, Song, Jianhua, McDaniel, J. Michael, Zhou, Meixiang, McGee, Samuel, Vanhoorelbeke, Karen, Bergmeier, Wolfgang, López, José A., George, James N., Xia, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029097/
https://www.ncbi.nlm.nih.gov/pubmed/35157766
http://dx.doi.org/10.1182/blood.2021012896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029097/
https://www.ncbi.nlm.nih.gov/pubmed/35157766
http://dx.doi.org/10.1182/blood.2021012896

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