Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases

In the field of drug discovery, the nitrile group is well represented among drugs and biologically active compounds. It can form both non-covalent and covalent interactions with diverse biological targets, and it is amenable as an electrophilic warhead for covalent inhibition. The main advantage of...

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Detalles Bibliográficos
Autores principales: Brogi, Simone, Ibba, Roberta, Rossi, Sara, Butini, Stefania, Calderone, Vincenzo, Gemma, Sandra, Campiani, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029279/
https://www.ncbi.nlm.nih.gov/pubmed/35458759
http://dx.doi.org/10.3390/molecules27082561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029279/
https://www.ncbi.nlm.nih.gov/pubmed/35458759
http://dx.doi.org/10.3390/molecules27082561

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