Mechanisms and Therapeutic Effects of Benzoquinone Ring Analogs in Primary CoQ Deficiencies

Coenzyme Q (CoQ) is a conserved polyprenylated lipid composed of a redox-active benzoquinone ring and a long polyisoprenyl tail that serves as a membrane anchor. CoQ biosynthesis involves multiple steps, including multiple modifications of the precursor ring 4-hydroxybenzoic acid. Mutations in the e...

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Detalles Bibliográficos
Autores principales: Pesini, Alba, Hidalgo-Gutierrez, Agustin, Quinzii, Catarina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029335/
https://www.ncbi.nlm.nih.gov/pubmed/35453349
http://dx.doi.org/10.3390/antiox11040665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029335/
https://www.ncbi.nlm.nih.gov/pubmed/35453349
http://dx.doi.org/10.3390/antiox11040665

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