Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer

TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding transcription factor activated by stressful stimuli; it upregulates target genes involved in growth suppression, cell death, DNA repair, metabolism, among others. TP53 is the most frequently mutated gene in tumors, with mut...

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Detalles Bibliográficos
Autores principales: Zhang, Shengliang, Carlsen, Lindsey, Hernandez Borrero, Liz, Seyhan, Attila A., Tian, Xiaobing, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029346/
https://www.ncbi.nlm.nih.gov/pubmed/35454137
http://dx.doi.org/10.3390/biom12040548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029346/
https://www.ncbi.nlm.nih.gov/pubmed/35454137
http://dx.doi.org/10.3390/biom12040548

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