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Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer

TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding transcription factor activated by stressful stimuli; it upregulates target genes involved in growth suppression, cell death, DNA repair, metabolism, among others. TP53 is the most frequently mutated gene in tumors, with mut...

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Detalles Bibliográficos
Autores principales:	Zhang, Shengliang, Carlsen, Lindsey, Hernandez Borrero, Liz, Seyhan, Attila A., Tian, Xiaobing, El-Deiry, Wafik S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029346/ https://www.ncbi.nlm.nih.gov/pubmed/35454137 http://dx.doi.org/10.3390/biom12040548

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