Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity

Platinum(IV) prodrugs of the [Pt(P(L))(A(L))(COXi)(OH)](2+) type scaffold (where P(L) is 1,10-phenanthroline or 5,6-dimethyl-1,10-phenanthroline, A(L) is 1S,2S-diaminocyclohexane, and COXi is a COX inhibitor, either indomethacin or aspirin) were synthesised and characterised, and their biological ac...

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Detalles Bibliográficos
Autores principales: Khoury, Aleen, Sakoff, Jennette A., Gilbert, Jayne, Scott, Kieran F., Karan, Shawan, Gordon, Christopher P., Aldrich-Wright, Janice R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029360/
https://www.ncbi.nlm.nih.gov/pubmed/35456621
http://dx.doi.org/10.3390/pharmaceutics14040787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029360/
https://www.ncbi.nlm.nih.gov/pubmed/35456621
http://dx.doi.org/10.3390/pharmaceutics14040787

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