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Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity
Platinum(IV) prodrugs of the [Pt(P(L))(A(L))(COXi)(OH)](2+) type scaffold (where P(L) is 1,10-phenanthroline or 5,6-dimethyl-1,10-phenanthroline, A(L) is 1S,2S-diaminocyclohexane, and COXi is a COX inhibitor, either indomethacin or aspirin) were synthesised and characterised, and their biological ac...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029360/ https://www.ncbi.nlm.nih.gov/pubmed/35456621 http://dx.doi.org/10.3390/pharmaceutics14040787 |