Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity

The inhibition of glycogen synthase kinase 3β (GSK3β) activity through pharmacological intervention represents a promising approach for treating challenging neurodegenerative disorders like Alzheimer’s disease. Similarly, abnormal tau aggregate accumulation in neurons is a hallmark of various neurod...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali, Taha F. S., Ciftci, Halil I., Radwan, Mohamed O., Roshdy, Eslam, Shawky, Ahmed M., Abourehab, Mohammed A. S., Tateishi, Hiroshi, Otsuka, Masami, Fujita, Mikako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029746/
https://www.ncbi.nlm.nih.gov/pubmed/35455423
http://dx.doi.org/10.3390/ph15040426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029746/
https://www.ncbi.nlm.nih.gov/pubmed/35455423
http://dx.doi.org/10.3390/ph15040426

Ejemplares similares