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The Effects of Various Food Products on Bisphosphonate’s Availability

The bioavailability of orally administered bisphosphonates is very low (<1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorpti...

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Autores principales: Zielińska, Monika, Garbacz, Grzegorz, Sczodrok, Jaroslaw, Voelkel, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029784/
https://www.ncbi.nlm.nih.gov/pubmed/35456551
http://dx.doi.org/10.3390/pharmaceutics14040717
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author Zielińska, Monika
Garbacz, Grzegorz
Sczodrok, Jaroslaw
Voelkel, Adam
author_facet Zielińska, Monika
Garbacz, Grzegorz
Sczodrok, Jaroslaw
Voelkel, Adam
author_sort Zielińska, Monika
collection PubMed
description The bioavailability of orally administered bisphosphonates is very low (<1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorption window. Therefore, the main goal of this study is to select a group of food products that are characterized by low binding affinity to bisphosphonates and thus will not reduce their availability upon concomitant administration. For this purpose, a combination of three methods was applied: (1) evaluation of sorption capacity for rows of digested food samples in a simulated intestinal environment; (2) evaluation of drug availability in simulated chyme; and (3) evaluation of drug availability using a simulating needle device. The results indicate that food products such as egg white and white bread are most suitable for consumption during oral bisphosphonate intake.
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spelling pubmed-90297842022-04-23 The Effects of Various Food Products on Bisphosphonate’s Availability Zielińska, Monika Garbacz, Grzegorz Sczodrok, Jaroslaw Voelkel, Adam Pharmaceutics Article The bioavailability of orally administered bisphosphonates is very low (<1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorption window. Therefore, the main goal of this study is to select a group of food products that are characterized by low binding affinity to bisphosphonates and thus will not reduce their availability upon concomitant administration. For this purpose, a combination of three methods was applied: (1) evaluation of sorption capacity for rows of digested food samples in a simulated intestinal environment; (2) evaluation of drug availability in simulated chyme; and (3) evaluation of drug availability using a simulating needle device. The results indicate that food products such as egg white and white bread are most suitable for consumption during oral bisphosphonate intake. MDPI 2022-03-27 /pmc/articles/PMC9029784/ /pubmed/35456551 http://dx.doi.org/10.3390/pharmaceutics14040717 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zielińska, Monika
Garbacz, Grzegorz
Sczodrok, Jaroslaw
Voelkel, Adam
The Effects of Various Food Products on Bisphosphonate’s Availability
title The Effects of Various Food Products on Bisphosphonate’s Availability
title_full The Effects of Various Food Products on Bisphosphonate’s Availability
title_fullStr The Effects of Various Food Products on Bisphosphonate’s Availability
title_full_unstemmed The Effects of Various Food Products on Bisphosphonate’s Availability
title_short The Effects of Various Food Products on Bisphosphonate’s Availability
title_sort effects of various food products on bisphosphonate’s availability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029784/
https://www.ncbi.nlm.nih.gov/pubmed/35456551
http://dx.doi.org/10.3390/pharmaceutics14040717
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