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The Effects of Various Food Products on Bisphosphonate’s Availability
The bioavailability of orally administered bisphosphonates is very low (<1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorpti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029784/ https://www.ncbi.nlm.nih.gov/pubmed/35456551 http://dx.doi.org/10.3390/pharmaceutics14040717 |
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author | Zielińska, Monika Garbacz, Grzegorz Sczodrok, Jaroslaw Voelkel, Adam |
author_facet | Zielińska, Monika Garbacz, Grzegorz Sczodrok, Jaroslaw Voelkel, Adam |
author_sort | Zielińska, Monika |
collection | PubMed |
description | The bioavailability of orally administered bisphosphonates is very low (<1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorption window. Therefore, the main goal of this study is to select a group of food products that are characterized by low binding affinity to bisphosphonates and thus will not reduce their availability upon concomitant administration. For this purpose, a combination of three methods was applied: (1) evaluation of sorption capacity for rows of digested food samples in a simulated intestinal environment; (2) evaluation of drug availability in simulated chyme; and (3) evaluation of drug availability using a simulating needle device. The results indicate that food products such as egg white and white bread are most suitable for consumption during oral bisphosphonate intake. |
format | Online Article Text |
id | pubmed-9029784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90297842022-04-23 The Effects of Various Food Products on Bisphosphonate’s Availability Zielińska, Monika Garbacz, Grzegorz Sczodrok, Jaroslaw Voelkel, Adam Pharmaceutics Article The bioavailability of orally administered bisphosphonates is very low (<1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorption window. Therefore, the main goal of this study is to select a group of food products that are characterized by low binding affinity to bisphosphonates and thus will not reduce their availability upon concomitant administration. For this purpose, a combination of three methods was applied: (1) evaluation of sorption capacity for rows of digested food samples in a simulated intestinal environment; (2) evaluation of drug availability in simulated chyme; and (3) evaluation of drug availability using a simulating needle device. The results indicate that food products such as egg white and white bread are most suitable for consumption during oral bisphosphonate intake. MDPI 2022-03-27 /pmc/articles/PMC9029784/ /pubmed/35456551 http://dx.doi.org/10.3390/pharmaceutics14040717 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zielińska, Monika Garbacz, Grzegorz Sczodrok, Jaroslaw Voelkel, Adam The Effects of Various Food Products on Bisphosphonate’s Availability |
title | The Effects of Various Food Products on Bisphosphonate’s Availability |
title_full | The Effects of Various Food Products on Bisphosphonate’s Availability |
title_fullStr | The Effects of Various Food Products on Bisphosphonate’s Availability |
title_full_unstemmed | The Effects of Various Food Products on Bisphosphonate’s Availability |
title_short | The Effects of Various Food Products on Bisphosphonate’s Availability |
title_sort | effects of various food products on bisphosphonate’s availability |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029784/ https://www.ncbi.nlm.nih.gov/pubmed/35456551 http://dx.doi.org/10.3390/pharmaceutics14040717 |
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