Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library

Small-molecule protein kinase inhibitors are used for the treatment of cancer, but off-target effects hinder their clinical use. Especially off-target activation of the pregnane X receptor (PXR) has to be considered, as it not only governs drug metabolism and elimination, but also can promote tumor...

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Detalles Bibliográficos
Autores principales: Mustonen, Enni-Kaisa, Pantsar, Tatu, Rashidian, Azam, Reiner, Juliander, Schwab, Matthias, Laufer, Stefan, Burk, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030254/
https://www.ncbi.nlm.nih.gov/pubmed/35455978
http://dx.doi.org/10.3390/cells11081299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030254/
https://www.ncbi.nlm.nih.gov/pubmed/35455978
http://dx.doi.org/10.3390/cells11081299

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