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In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL
MscL is a highly conserved mechanosensitive channel found in the majority of bacterial species, including pathogens. It functions as a biological emergency release valve, jettisoning solutes from the cytoplasm upon acute hypoosmotic stress. It opens the largest known gated pore and has been heralded...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030384/ https://www.ncbi.nlm.nih.gov/pubmed/35453186 http://dx.doi.org/10.3390/antibiotics11040433 |