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Mapping the Key Residues within the Porcine Reproductive and Respiratory Syndrome Virus nsp1α Replicase Protein Required for Degradation of Swine Leukocyte Antigen Class I Molecules

The nonstructural protein 1α (nsp1α) of the porcine reproductive and respiratory syndrome virus (PRRSV) has been shown to target swine leukocyte antigen class I (SLA-I) for degradation, but the molecular details remain unclear. In this report, we further mapped the critical residues within nsp1α by...

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Detalles Bibliográficos
Autores principales: Liu, Yuanyuan, Gao, Peng, Zhou, Lei, Ge, Xinna, Zhang, Yongning, Guo, Xin, Han, Jun, Yang, Hanchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030574/
https://www.ncbi.nlm.nih.gov/pubmed/35458420
http://dx.doi.org/10.3390/v14040690