The BCAT1 CXXC Motif Provides Protection against ROS in Acute Myeloid Leukaemia Cells

The cytosolic branched-chain aminotransferase (BCAT1) has received attention for its role in myeloid leukaemia development, where studies indicate metabolic adaptations due to BCAT1 up-regulation. BCAT1, like the mitochondria isoform (BCAT2), shares a conserved CXXC motif ~10 Å from the active site....

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Detalles Bibliográficos
Autores principales: Hillier, James, Allcott, Gemma J., Guest, Laura A., Heaselgrave, Wayne, Tonks, Alex, Conway, Myra E., Cherry, Amy L., Coles, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030579/
https://www.ncbi.nlm.nih.gov/pubmed/35453368
http://dx.doi.org/10.3390/antiox11040683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030579/
https://www.ncbi.nlm.nih.gov/pubmed/35453368
http://dx.doi.org/10.3390/antiox11040683

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