Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

Piperlongumine, a natural alkaloid substance extracted from the fruit of the long pepper (Piper longum Linn.), is known to inhibit the cytosolic thioredoxin reductase (TXNRD1 or TrxR1) and selectively kill cancer cells. However, the details and mechanism of the inhibition by piperlongumine against T...

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Detalles Bibliográficos
Autores principales: Yang, Yijia, Sun, Shibo, Xu, Weiping, Zhang, Yue, Yang, Rui, Ma, Kun, Zhang, Jie, Xu, Jianqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030593/
https://www.ncbi.nlm.nih.gov/pubmed/35453395
http://dx.doi.org/10.3390/antiox11040710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030593/
https://www.ncbi.nlm.nih.gov/pubmed/35453395
http://dx.doi.org/10.3390/antiox11040710

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