Structural Insights from Molecular Modeling of Isoindolin-1-One Derivatives as PI3Kγ Inhibitors against Gastric Carcinoma

The upregulation of phosphoinositol-3-kinase γ (PI3Kγ) is deemed to be positively correlated with tumor-associated-macrophage (TAM)-mediated gastric carcinoma (GC). PI3Kγ suppresses tumor necrosis factor-alpha (TNF-α) and interleukin-12 (IL-12) through activation of the AKT/mTOR pathway, which promo...

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Detalles Bibliográficos
Autores principales: Ghosh, Suparna, Cho, Seung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030798/
https://www.ncbi.nlm.nih.gov/pubmed/35453562
http://dx.doi.org/10.3390/biomedicines10040813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030798/
https://www.ncbi.nlm.nih.gov/pubmed/35453562
http://dx.doi.org/10.3390/biomedicines10040813

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