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Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2

SOCS3 (suppressor of cytokine signaling 3) protein suppresses cytokine-induced inflammation and its deletion in neurons or immune cells increases the pathological growth of blood vessels. Recently, we designed several SOCS3 peptidomimetics by assuming as template structures the interfacing regions o...

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Detalles Bibliográficos
Autores principales: La Manna, Sara, Leone, Marilisa, Mercurio, Flavia Anna, Florio, Daniele, Marasco, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031227/
https://www.ncbi.nlm.nih.gov/pubmed/35455455
http://dx.doi.org/10.3390/ph15040458